<!DOCTYPE html> <html> <head> <style> option {color: blue} option:disabled {color: green} option#one:not([disabled]):enabled + option#two {color: red} </style> </head> <body onload='var elem = document.getElementById("one"); elem.setAttribute("disabled", "disabled");'> <select size="2"> <option id="one">Should be green</option> <option id="two">Should be blue</option> </select> </body> </html>